The Trichoplax genome and the nature of placozoans

被引：626

作者：

Srivastava, Mansi ^{[1
,2
]}

Begovic, Emina ^{[1
,2
,3
]}

Chapman, Jarrod ^{[3
]}

Putnam, Nicholas H. ^{[3
]}

Hellsten, Uffe ^{[3
]}

Kawashima, Takeshi ^{[1
,2
,4
]}

Kuo, Alan ^{[3
]}

Mitros, Therese ^{[1
,2
]}

Salamov, Asaf ^{[3
]}

Carpenter, Meredith L. ^{[1
,2
]}

Signorovitch, Ana Y. ^{[5
,6
]}

Moreno, Maria A. ^{[5
]}

Kamm, Kai ^{[8
]}

Grimwood, Jane ^{[9
]}

Schmutz, Jeremy ^{[9
]}

Shapiro, Harris ^{[3
]}

Grigoriev, Igor V. ^{[3
]}

Buss, Leo W. ^{[6
,7
]}

Schierwater, Bernd ^{[5
,8
]}

Dellaporta, Stephen L. ^{[5
]}

Rokhsar, Daniel S. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Ctr Integrat Genom, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Dept Energy Joint Genome Inst, Walnut Creek, CA 94598 USA

[4] Okinawa Inst Sci & Technol, Okinawa 9042234, Japan

[5] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[6] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA

[7] Yale Univ, Dept Geol & Geophys, New Haven, CT 06520 USA

[8] Stiftung Tieraerztliche Hochsch Hannover, Div Ecol & Evolut, Inst Tierokol & Zellbiol, D-30559 Hannover, Germany

[9] Stanford Univ, Stanford Human Genome Ctr, Palo Alto, CA 94304 USA

来源：

NATURE | 2008年 / 454卷 / 7207期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nature07191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As arguably the simplest free- living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the similar to 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole- genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome shows conserved gene content, gene structure and synteny in relation to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signalling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/ or as yet unobserved life history stages.

引用

页码：955 / U19

页数：7

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