Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

被引：24

作者：

Kamino, Shinichiro ^{[1
]}

Ichikawa, Hayato ^{[1
]}

Wada, Shun-ichi ^{[1
]}

Horio, Yuka ^{[1
]}

Usami, Yoshihide ^{[1
]}

Yamaguchi, Takako ^{[1
]}

Koda, Toshiki ^{[1
]}

Harada, Aki ^{[1
]}

Shimanuki, Kazusa ^{[1
]}

Arimoto, Masao ^{[1
]}

Doi, Mitsunobu ^{[1
]}

Fujita, Yoshikazu ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 15期

关键词：

unsymmetrical xanthene derivatives; regioisomerically pure; photochemical properties; chemical biology;

D O I：

10.1016/j.bmcl.2008.06.065

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4380 / 4384

页数：5

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