Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids

被引:393
作者
Adkins, Yuriko
Kelley, Darshan S. [1 ]
机构
[1] Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
关键词
Omega 3 polyunsaturated fatty acids; Cardiovascular disease; Atherosclerosis; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ALPHA-LINOLENIC ACID; SMOOTH-MUSCLE-CELLS; LONG-CHAIN N-3; FACTOR-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; PUBLIC-HEALTH PRACTICE; SUDDEN CARDIAC DEATH; TOLL-LIKE RECEPTOR-4;
D O I
10.1016/j.jnutbio.2009.12.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Typical omega 3 polyunsaturated fatty acids (n-3 PUFAs) are docosahexaenoic acid and eicosapentaenoic acid in the form of fish oils and a linolenic acid from flaxseed oil. Epidemiological studies suggested the benefits of n-3 PUFA on cardiovascular health Intervention studies confirmed that the consumption of n-3 PUFA provided benefits for primary and secondary prevention of cardiovascular disease. Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects n-3 PUFAs inhibit inflammatory signaling pathways (nuclear factor-kappa B activity) and down-regulate fatty acid (FA) synthesis gene expression (sterol regulatory element binding protein-1c) and up-regulate gene expression involved in FA oxidation (peroxisome proliferator-activated receptor alpha) This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD. Published by Elsevier Inc
引用
收藏
页码:781 / 792
页数:12
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