Experimental tests of the Peyrard-Bishop model applied to the melting of very short DNA chains

被引:200
作者
Campa, A
Giansanti, A
机构
[1] Ist Super Sanita, Phys Lab, I-00161 Rome, Italy
[2] Ist Nazl Fis Nucl, I-00161 Rome, Italy
[3] Univ Rome La Sapienza, Dept Phys, I-00185 Rome, Italy
[4] INFM, Unita Roma 1, I-00185 Rome, Italy
来源
PHYSICAL REVIEW E | 1998年 / 58卷 / 03期
关键词
D O I
10.1103/PhysRevE.58.3585
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
The melting curves of short heterogeneous DNA chains in solution are calculated on the basis of statistical thermodynamics, and compared to experiments. The computation of the partition function is based on the Peyrard-Bishop Hamiltonian, which has already been adopted in a theoretical description of the melting of long DNA chains. In the case of short chains it is necessary to consider not only the breaking of the hydrogen bonds between single base pairs, but also the complete dissociation of the two strands forming the double helix.
引用
收藏
页码:3585 / 3588
页数:4
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