An efficient synthesis of 4-oxoalkenoic acids from 2-alkylfurans

被引：32

作者：

Annangudi, SP ^{[1
]}

Sun, MJ ^{[1
]}

Salomon, RG ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

来源：

SYNLETT | 2005年 / 09期

关键词：

furan oxidation; sodium chlorite; ring opening; oxidized phospholipids; alpha; beta-unsaturated acids;

D O I：

10.1055/s-2005-869833

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

An efficient synthesis of 4-oxo-2-alkenoic acids is achieved by the reaction of 2-alkylfurans with sodium chlorite in acidic aqueous solution. The method is applicable to the total synthesis of biologically active phospholipids containing this functional array. The oxidation procedure also converts 2,5-dialkyl furans to alpha,beta-unsaturated-gamma-diketones in good yields.

引用

页码：1468 / 1470

页数：3

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