Polyether-modified poly(acrylic acid): Synthesis and applications

被引:85
作者
Bromberg, L [1 ]
机构
[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
关键词
D O I
10.1021/ie980358s
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Poly(acrylic acid) (PAA) copolymers modified with block-copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) are inherently attractive for medicinal applications as their components are considered pharmaceutically safe. The laboratory-scale synthesis of poly(acrylic acid) bonded onto a PEO-PPO-PEO triblock (Pluronic) backbone via dispersion polymerization is reported. Initial optimization of the synthesis defines appropriate levels of initial loading of acrylic acid and Pluronic, with a mixture of 2,2'-azobis(2,4-dimethylpentanenitrile) and lauroyl peroxide as an initiator system. The synthesis results in a copolymer with low residual monomer content and a very high degree of bonding between Pluronic and PAA. Diluted aqueous solutions of Pluronic-g-PAA exhibit rapid thermogelation. Rheological parameters of the copolymers urge on their ophthalmic applications.
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页码:4267 / 4274
页数:8
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