Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients

被引：37

作者：

Buraczynska, Monika ^{[1
]}

Swatowski, Andrzej ^{[1
]}

Markowska-Gosik, Dorota ^{[1
]}

Kuczmaszewska, Agata ^{[1
]}

Ksiazek, Andrzej ^{[1
]}

机构：

[1] Med Univ Lublin, Lab DNA Anal & Mol Diagnost, Dept Nephrol, PL-20954 Lublin, Poland

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2011年 / 93卷 / 03期

关键词：

Diabetic nephropathy; Gene polymorphism; Risk alleles; TCF7L2; Type; 2; diabetes; GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; RISK LOCI; SUSCEPTIBILITY; POPULATION; REPLICATION; VARIANTS; GLUCOSE;

D O I：

10.1016/j.diabres.2011.05.017

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Transcription factor 7-like 2 gene (TCF7L2) has been associated with type 2 diabetes. We investigated the association of the rs7903146 SNP in this gene with clinical profile of type 2 diabetes (T2DM) patients. The study involved 980 patients with diabetic nephropathy (44%), diabetic retinopathy (42%), CVD (65%) and early onset of diabetes (45%) and 924 healthy controls. Subjects were genotyped for rs7903146 by PCR-RFLP. Genotype frequencies significantly differed between T2DM patients and controls (p < 0.01, odds ratio (OR) for TT genotype 2.49 (95% confidence interval (CI) 1.84-3.39). An association was observed between rs7903146 and nephropathy (p < 0.001), with 22% of TT homozygotes in this subgroup vs. 11% in patients without nephropathy (p = 0.006, OR for TT 2.83, 95% CI 1.94-4.13). Association was stronger in patients with early onset of diabetes (34% of TT vs. 12% in the late onset, p < 0.001). In DN group 71% of TT homozygotes had an early onset (OR 7.64, 95% CI 4.98-11.73 vs. controls). Our results confirm association of rs7903146 in the TCF7L2 gene with increased risk of type 2 diabetes. The T allele is strongly associated with nephropathy, especially in early onset of diabetes. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：390 / 395

页数：6

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