Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription

被引：55

作者：

Yan, Rui ^{[1
]}

Wang, Yin ^{[1
]}

Shen, Wenjin ^{[1
]}

Liu, Youping ^{[1
]}

Di, Xin ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 08期

关键词：

Dehydroevodiamine; Coptisine; Rhizoma coptidis-Evodia rutaecarpa couple; Liquid chromatography-tandem mass spectrometry; Pharmacokinetics; TANDEM MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHIC DETERMINATION; BERBERINE; PALMATINE; JATRORRHIZINE; EVODIAMINE; BAICALIN; COPTIDIS; RHIZOMA; COUPLE;

D O I：

10.1016/j.fitote.2011.07.012

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Zuojinwan, which consists of Rhizoma coptidis-Evodia rutaecarpa powder (6:1,g/g), is a traditional Chinese medicine (TCM) prescription, clinically used for the treatment of gastrointestinal disorders. This study compared the pharmacokinetics of dehydroevodiamine and coptisine, the main active ingredients in Zuojinwan, in rats administrated with whole prescription or single herbs. Multiple blood concentration peaks were observed in the mean plasma-concentration curves. The pharmacokinetic parameters were quite different between single herbs and Zuojinwan prescription. Moreover, the mean plasma concentration of dehydroevodiamine increased and the one of coptisine decreased after combining, which was in accord with the clinical principle of TCM. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：1152 / 1159

页数：8

相关论文

共 18 条

[1]

China Pharmacopoeia Committee, 2005, CHIN PHARM, V1, p[118, 213]

[2]

Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple [J].

Deng, Yating ;

Liao, Qiongfeng ;

Li, Suhua ;

Bi, Kaishun ;

Pan, Biyan ;

Xie, Zhiyong .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 863 (02) :195-205

[3]

Pharmacokinetic comparisons of Shuang-Huang-Lian with the different combinations of its constitutional herbs [J].

Di, Bin ;

Feng, Nianping ;

Liu, Wenying .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 107 (03) :401-405

[4]

Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple [J].

Feng, Jin ;

Xu, Wen ;

Tao, Xia ;

Wei, Hua ;

Cal, Fei ;

Jiang, Bo ;

Chen, Wansheng .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 53 (03) :591-598

[5]

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF EVODIAMINE IN RAT PLASMA - APPLICATION TO PHARMACOKINETIC STUDIES [J].

JENG, KF ;

LIN, YH ;

LIN, LC ;

CHOU, CJ ;

TSAI, TH ;

CHEN, CF .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 668 (02) :343-345

[6]

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF RUTAECARPINE IN RAT PLASMA - APPLICATION TO A PHARMACOKINETIC STUDY [J].

KO, HC ;

TSAI, TH ;

CHOU, CJ ;

HSU, SY ;

LI, SY ;

CHEN, CF .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 655 (01) :27-31

[7]

In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from Gan-kang granules and extracts of Herba Epimedii, Nepal dock root, Ficus hirta yahl [J].

Li, Yihui ;

Duan, Juping ;

Guo, Tingting ;

Xie, Wei ;

Yan, Shineng ;

Li, Bo ;

Zhou, Yanqin ;

Chen, Yuxiang .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 124 (03) :522-529

[8]

Liao Qiong-Feng, 2008, Zhong Yao Cai, V31, P673

[9]

Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method [J].

Lu, T ;

Liang, Y ;

Song, J ;

Xie, L ;

Wang, GJ ;

Liu, XD .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (05) :1218-1224

[10]

Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats [J].

Lu, Tong ;

Song, Jue ;

Huang, Fang ;

Deng, Yuanxiong ;

Xie, Lin ;

Wang, Guangji ;

Liu, Xiaodong .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 110 (03) :412-418