Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time

被引:31
作者
Lerner, RG
Nelson, J
Sorcia, E
Grima, K
Kancherla, RR
Zarou-Naimo, CM
Pehta, JC
机构
[1] New York Med Coll, Dept Med, Hematol Sect, Valhalla, NY 10595 USA
[2] New York Med Coll, Transfus Serv, Valhalla, NY 10595 USA
[3] Westchester Cty Med Ctr, Valhalla, NY 10595 USA
[4] VI Technol Inc, Watertown, MA USA
关键词
D O I
10.1046/j.1423-0410.2000.7930161.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP), Methods: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to less than or equal to 15 s in patients with acquired coagulation deficits, Results: 45 patients (22 SDP vs, 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46], percentage of patients who corrected their PT to less than or equal to 15 s (32% for SDP vs, 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). Conclusion: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:161 / 167
页数:7
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