The protein-conducting channel SecYEG

被引：99

作者：

Veenendaal, AKJ ^{[1
]}

van der Does, C ^{[1
]}

Driessen, AM ^{[1
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9750 AA Haren, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1694卷 / 1-3期

关键词：

protein-conducting channel; translocase; SecYEG; protein translocation; secretion;

D O I：

10.1016/j.bbamcr.2004.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In bacteria, the translocase mediates the translocation of proteins into or across the cytosolic membrane. It consists of a membrane embedded protein-conducting channel and a peripherally associated motor domain, the ATPase SecA. The channel is formed by SecYEG, a multimeric protein complex that assembles into oligomeric forms. The structure and subunit composition of this protein-conducting channel is evolutionary conserved and a similar system is found in the endoplasmic reticulum of eukaryotes and cytoplasmic membrane of archaea. The ribosome and other membrane proteins can associate with the protein-conducting channel complex and affect its activity or functionality. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：81 / 95

页数：15

共 177 条

[1] RECONSTITUTION OF A PROTEIN TRANSLOCATION SYSTEM CONTAINING PURIFIED SECY, SECE, AND SECA FROM ESCHERICHIA-COLI
AKIMARU, J
MATSUYAMA, SI
TOKUDA, H
MIZUSHIMA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (15) : 6545 - 6549
[2] SECA, AN ESSENTIAL COMPONENT OF THE SECRETORY MACHINERY OF ESCHERICHIA-COLI, EXISTS AS HOMODIMER
AKITA, M
SHINKAI, A
MATSUYAMA, S
MIZUSHIMA, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (01) : 211 - 216
[3] TOPOLOGY ANALYSIS OF THE SECY PROTEIN, AN INTEGRAL MEMBRANE-PROTEIN INVOLVED IN PROTEIN EXPORT IN ESCHERICHIA-COLI
AKIYAMA, Y
ITO, K
[J]. EMBO JOURNAL, 1987, 6 (11) : 3465 - 3470
[4] THE GENES FOR RIBOSOMAL-PROTEIN L15 AND THE PROTEIN EQUIVALENT TO SECY IN THE ARCHAEBACTERIUM HALOARCULA (HALOBACTERIUM) MARISMORTUI
ARNDT, E
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1130 (01) : 113 - 116
[5] PRESENCE OF A GENE IN THE ARCHAEBACTERIUM METHANOCOCCUS-VANNIELII HOMOLOGOUS TO SECY OF EUBACTERIA
AUER, J
SPICKER, G
BOCK, A
[J]. BIOCHIMIE, 1991, 73 (06) : 683 - 688
[6] A CYTOPLASMIC DOMAIN IS IMPORTANT FOR THE FORMATION OF A SECY-SECE - TRANSLOCATOR COMPLEX
BABA, T
TAURA, T
SHIMOIKE, T
AKIYAMA, Y
YOSHIHISA, T
ITO, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) : 4539 - 4543
[7] PROPER INTERACTION BETWEEN AT LEAST 2 COMPONENTS IS REQUIRED FOR EFFICIENT EXPORT OF PROTEINS TO THE ESCHERICHIA-COLI CELL-ENVELOPE
BANKAITIS, VA
BASSFORD, PJ
[J]. JOURNAL OF BACTERIOLOGY, 1985, 161 (01) : 169 - 178
[8] YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids
Beck, K
Eisner, G
Trescher, D
Dalbey, RE
Brunner, J
Müller, M
[J]. EMBO REPORTS, 2001, 2 (08) : 709 - 714
[9] Architecture of the protein-conducting channel associated with the translating 80S ribosome
Beckmann, R
Spahn, CMT
Eswar, N
Helmers, J
Penczek, PA
Sali, A
Frank, J
Blobel, G
[J]. CELL, 2001, 107 (03) : 361 - 372
[10] Alignment of conduits for the nascent polypeptide chain in the Ribosome-Sec61 complex
Beckmann, R
Bubeck, D
Grassucci, R
Penczek, P
Verschoor, A
Blobel, G
Frank, J
[J]. SCIENCE, 1997, 278 (5346) : 2123 - 2126

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