The protein-conducting channel SecYEG

被引：99

作者：

Veenendaal, AKJ ^{[1
]}

van der Does, C ^{[1
]}

Driessen, AM ^{[1
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9750 AA Haren, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1694卷 / 1-3期

关键词：

protein-conducting channel; translocase; SecYEG; protein translocation; secretion;

D O I：

10.1016/j.bbamcr.2004.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In bacteria, the translocase mediates the translocation of proteins into or across the cytosolic membrane. It consists of a membrane embedded protein-conducting channel and a peripherally associated motor domain, the ATPase SecA. The channel is formed by SecYEG, a multimeric protein complex that assembles into oligomeric forms. The structure and subunit composition of this protein-conducting channel is evolutionary conserved and a similar system is found in the endoplasmic reticulum of eukaryotes and cytoplasmic membrane of archaea. The ribosome and other membrane proteins can associate with the protein-conducting channel complex and affect its activity or functionality. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：81 / 95

页数：15

共 177 条

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