Circadian proteins in the regulation of cell cycle and genotoxic stress responses

被引：89

作者：

Kondratov, Roman V.

Antoch, Marina P. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA

[2] Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 07期

关键词：

DNA-REPLICATION; DROSOPHILA-TIMELESS; CHECKPOINT RESPONSE; INTERACTING PROTEIN; MAMMALIAN TIMELESS; CKI-EPSILON; CLOCK GENES; S-PHASE; MOUSE; TIPIN;

D O I：

10.1016/j.tcb.2007.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian circadian system has been implicated in the regulation of the genotoxic stress response of an organism; however, the underlying molecular mechanisms are not well understood. Recent data suggest that, in addition to circadian variations in the expression of genes involved in genotoxic stress responses, core circadian proteins PERIOD1 (PER1) and TIMELESS (TIM) interact with components of the cell cycle checkpoint system, such as ataxia telangiectasia mutated (ATM)checkpoint kinase 2 (Chk2) and ataxia telangiectasia and Rad3-related (ATR)-Chk1, and are necessary for activation of Chk1 and Chk2 by DNA damage. Moreover, in complex with its recently identified partner, TIM-interacting protein (TIPIN), TIM interacts with components of the DNA replication system to regulate DNA replication processes under both normal and stress conditions. These discoveries shed new light on the role of core circadian proteins in various cellular and physiological processes.

引用

页码：311 / 317

页数：7

共 57 条

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