The Biology of Aging and Frailty

被引：222

作者：

Fedarko, Neal S. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, Dept Med, Baltimore, MD 21224 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2011年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Frailty; Aging; Apoptosis; Senescence; Inflammation; NF-KAPPA-B; PROGRAMMED CELL-DEATH; SKELETAL-MUSCLE; DEGENERATIVE DISEASES; MOLECULAR-MECHANISMS; CHRONIC INFLAMMATION; SERUM INTERLEUKIN-6; OXIDATIVE DAMAGE; WOMENS HEALTH; DNA-DAMAGE;

D O I：

10.1016/j.cger.2010.08.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In developing and validating the concept of frailty as a geriatric syndrome, it has been necessary to distinguish the clinical expression of frailty from normal age-related changes and other age-related disease pathologies. A framework for excluding potentially confounding disease and a working clinical tool to diagnose frailty have been provided. The associations between frailty and other pathophysiologies has also been shown. However, investigating the underlying biologic basis for the geriatric syndrome of frailty by studying basic homeostatic pathways and mechanisms has not proceeded at the same rate. The following article provides an overview of the homeostatic pathways emphasized in research on aging and explains how this science may help to stimulate frailty research.

引用

页码：27 / +

页数：12