Cytotoxic sugar analogues of an optimized novobiocin scaffold

被引：29

作者：

Donnelly, Alison C. ^{[1
]}

Zhao, Huiping ^{[1
]}

Kusuma, Bhaskar Reddy ^{[1
]}

Blagg, Brian S. J. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

MEDCHEMCOMM | 2010年 / 1卷 / 02期

关键词：

INHIBITORS; DESIGN; HSP90; AGENTS;

D O I：

10.1039/c0md00063a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on the natural product, novobiocin, have elucidated specific modifications that increase Hsp90 inhibition Through diversification of the sugar appendage, coumarin core and benzamide side chain of novobiocin, structurally unique scaffolds have been synthesized These structural adaptations have produced potent cytotoxic agents, such as KU135, which are prepared more simply than those that contain the noviose sugar These analogues have been evaluated against two cancer cell lines and demonstrated low micromolar anti-proliferative activity

引用

页码：165 / 170

页数：6

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