Trachycladindoles A-G:: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer

被引：30

作者：

Capon, Robert J. ^{[1
]}

Peng, Chongsheng ^{[2
]}

Dooms, Cedric ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200249, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 15期

关键词：

D O I：

10.1039/b803455a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A southern Australian marine sponge, Trachycladus laevispirulifer, yielded the cytotoxic agents trachycladindoles A-G (1-7) as a selection of novel indole-2-carboxylic acids bearing a 2-amino-4,5-dihydroimidazole moiety. The trachycladindoles displayed promising selective cytotoxicity against a panel of human cancer cell lines and their structures were assigned on the basis of detailed spectroscopic analysis. Preliminary structure activity relationship (SAR) investigations by co-metabolite defined structural features key to the trachycladindole pharmacophore, highlighting an unusual bioactive molecular motif deserving of future investigation.

引用

页码：2765 / 2771

页数：7

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