Towards an understanding of the molecular basis of herpes simplex virus latency

被引:73
作者
Efstathiou, S
Preston, CM
机构
[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England
[2] MRC, Virol Unit, Inst Virol, Glasgow G11 5JR, Lanark, Scotland
基金
英国医学研究理事会;
关键词
herpes; simplex; virus; latency; reactivation; neuron; gene regulation; histone modification; apoptosis;
D O I
10.1016/j.virusres.2005.04.017
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The survival strategy of herpes simplex virus centres on the establishment of latency in sensory neurons innervating the site of primary infection followed by periodic reactivation to facilitate transmission. This is a highly evolved and efficient survival mechanism, which despite being the subject of intense research, has proven remarkably difficult to dissect at a molecular level. This review will focus on data, emerging from both in vitro and in vivo model systems, which provide a framework for a mechanistic understanding of latency and the existence and possible significance of non-uniform latent states. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:108 / 119
页数:12
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