17q21-qter trisomy is an indicator of poor prognosis in acute myelogenous leukemia

被引：6

作者：

Morerio, C

Russo, I

Rosanda, C

Rapella, A

Leszl, A

Basso, G

Maserati, E

Pasquali, F

Panarello, C

机构：

[1] Ist Giannina Gaslini, Div Ematol & Oncol Pediat, I-16147 Genoa, Italy

[2] Univ Padua, Dipartimento Pediat Clin Pediat, Padua, Italy

[3] Univ Turin, Dipartimento Pediat, I-10124 Turin, Italy

[4] Univ Pavia, I-27100 Pavia, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 124卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(99)00229-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A reciprocal translocation (9;11) is often found in acute myeloid leukemia (AML), mostly of the M5a type. We report a case of a child with ARAL, in whom r(9;11) was observed at diagnosis as the sole structural abnormality, together vith trisomies 19 and 21. The diagnosis was AML evolving from a myelodysplastic syndrome (MDS), and the blast morphology was undifferentiated. Chemotherapy failed to induce morphological remission and the patient's condition soon worsened. A subclone appeared and expanded during the course of the disease, with an additional unbalanced translocation (1;17) leading to trisomy of the long arm of chromosome 17 (17q). The data available from the literature on acquired anomalies involving 17q and our observation led us to postulate a specific link; between the gain of 17q and complete chemoresistance. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：12 / 15

页数：4

共 25 条

[11] LOCALIZATION OF THE HUMAN ESTROGEN-RESPONSIVE FINGER PROTEIN (EFP) GENE (ZNF147) WITHIN A YAC CONTIG CONTAINING THE MYELOPEROXIDASE (MPO) GENE [J].

LAW, DJ ;

PRASAD, MA ;

KING, SE ;

SPRANGER, KD ;

LEE, YH ;

FOX, RE ;

COLLINS, EE ;

GEBUHR, TC ;

MILLER, DE ;

PETTY, EM .

GENOMICS, 1995, 28 (02) :361-363

[12] ABNORMALITIES OF CHROMOSOME BAND-11Q23 AND THE MLL GENE IN PEDIATRIC MYELOMONOCYTIC AND MONOBLASTIC LEUKEMIAS - IDENTIFICATION OF THE T(9-11) AS AN INDICATOR OF LONG SURVIVAL [J].

MARTINEZCLIMENT, JA ;

ESPINOSA, R ;

THIRMAN, MJ ;

LEBEAU, MM ;

ROWLEY, JD .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1995, 17 (04) :277-283

[13]

Meddeb M, 1996, GENE CHROMOSOME CANC, V17, P156, DOI 10.1002/(SICI)1098-2264(199611)17:3<156::AID-GCC3>3.0.CO

[14]

2-3

[15]

MITELMAN F, 1990, AM J MED GENET, P262

[16]

Mitelman F., 1994, CATALOG CHROMOSOME A

[17]

Mrozek K, 1997, BLOOD, V90, P4532

[18] Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation [J].

Panarello, C ;

Morerio, C ;

Russo, I ;

Pasquali, F ;

Rapella, A ;

Corrias, MV ;

Morando, A ;

Rosanda, C .

CANCER GENETICS AND CYTOGENETICS, 2000, 116 (02) :124-132

[19]

PROTOCKI L, 1994, CANCER GENET CYTOGEN, V74, P66

[20]

Raimondi SC, 1996, LEUKEMIA, V10, P213

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