Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report

被引：137

作者：

Ben-Menachem, Elinor ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Clin Neurosci & Physiol, Sahlgenska Univ Hosp, Gothenburg, Sweden

来源：

EPILEPSIA | 2007年 / 48卷

关键词：

epilepsy; antiepileptic drugs; weight issues;

D O I：

10.1111/j.1528-1167.2007.01402.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Weight gain or loss is not an integral part of epilepsy although a sedentary lifestyle can contribute to weight gain. Pharmacological treatment for epilepsy may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. Antiepileptic drugs (AEDs) associated with weight loss are felbamate, topiramate, and zonisamide. AEDs associated with weight gain are gabapentin, pregabalin, valproic acid, and vigabatrin and possibly, carbamazepine. Weight neutral AEDs are lamotrigine, levetiracetam, and phenytoin. In clinical practice it is critical to weigh patients regularly and AED selection should be based on each patient's profile without sacrificing therapeutic efficacy.

引用

页码：42 / 45

页数：4

共 21 条

[1] Randomized dose-controlled study of topiramate as first-line therapy in epilepsy [J].

Arroyo, S ;

Dodson, WE ;

Privitera, MD ;

Glauser, TA ;

Naritoku, DK ;

Dlugos, DJ ;

Wang, S ;

Schwabe, SK ;

Twyman, RE .

ACTA NEUROLOGICA SCANDINAVICA, 2005, 112 (04) :214-222

[2] Pregabalin add-on treatment: A randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures [J].

Arroyo, S ;

Anhut, H ;

Kugler, AR ;

Lee, CM ;

Knapp, LE ;

Garofalo, EA ;

Messmer, S .

EPILEPSIA, 2004, 45 (01) :20-27

[3] Predictors of weight loss in adults with topiramate-treated epilepsy [J].

Ben-Menachem, E ;

Axelsen, M ;

Johanson, EH ;

Stagge, A ;

Smith, U .

OBESITY RESEARCH, 2003, 11 (04) :556-562

[4] Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy [J].

Beydoun, A ;

Uthman, BM ;

Kugler, AR ;

Greiner, MJ ;

Knapp, LE ;

Garofalo, EA .

NEUROLOGY, 2005, 64 (03) :475-480

[5] Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy [J].

Biton, V ;

Mirza, W ;

Montouris, G ;

Vuong, A ;

Hammer, AE ;

Barrett, PS .

NEUROLOGY, 2001, 56 (02) :172-177

[6] The long-term use of felbamate in children with severe refractory epilepsy [J].

Cilio, MR ;

Kartashov, AI ;

Vigevano, F .

EPILEPSY RESEARCH, 2001, 47 (1-2) :1-7

[7] Changes in body weight with chronic, high-dose gabapentin therapy [J].

DeToledo, JC ;

Toledo, C ;

DeCerce, J ;

Ramsay, RE .

THERAPEUTIC DRUG MONITORING, 1997, 19 (04) :394-396

[8] Stable weight during lamotrigine therapy: A review of 32 studies [J].

Devinsky, O ;

Vuong, A ;

Hammer, A ;

Barrett, PS .

NEUROLOGY, 2000, 54 (04) :973-975

[9] Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures [J].

Faught, E ;

Ayala, R ;

Montouris, GG ;

Leppik, IE .

NEUROLOGY, 2001, 57 (10) :1774-1779

[10] A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis [J].

Freitag, FG ;

Collins, SD ;

Carlson, HA ;

Goldstein, J ;

Saper, J ;

Silberstein, S ;

Mathew, N ;

Winner, PK ;

Deaton, R ;

Sommerville, K .

NEUROLOGY, 2002, 58 (11) :1652-1659

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