Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

被引：21

作者：

Kofman, O

Agam, G

Shapiro, J

Spencer, A

机构：

[1] Ben Gurion Univ Negev, Dept Behav Sci, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Dept Clin Biochem, IL-84105 Beer Sheva, Israel

来源：

PSYCHOPHARMACOLOGY | 1998年 / 139卷 / 03期

关键词：

inositol; locomotor behaviour; rearing;

D O I：

10.1007/s002130050710

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. The present study examined the effects of chronic dietary inositol in rats on locomotor behaviour. Regional brain levels of inositol were analyzed by gas chromatography. Chronic dietary inositol significantly enhanced locomotion and rearing in rats and elevated inositol levels by 36% in the cortex and 27% in hippocampus. No differences in inositol levels were found in the striatum or cerebellum. The stimulatory effects of inositol may be related to its effects as an atypical antidepressant in depressed patients.

引用

页码：239 / 242

页数：4

共 29 条

[1] HIGH-DOSE PERIPHERAL INOSITOL RAISES BRAIN INOSITOL LEVELS AND REVERSES BEHAVIORAL-EFFECTS OF INOSITOL DEPLETION BY LITHIUM [J].