Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

被引：167

作者：

Vicent, MJ

Greco, F

Nicholson, RI

Paul, A

Griffiths, PC

Duncan, R

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Ctr Polymer Therapeut, Cardiff CF10 3XF, Wales

[2] Cardiff Univ, Welsh Sch Pharm, Tenovus Ctr Canc Res, Cardiff CF10 3XF, Wales

[3] Cardiff Univ, Sch Chem, Cardiff CF10 3TB, Wales

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 26期

关键词：

antitumor agents; drug delivery; drug design; polymers; tumor targeting;

D O I：

10.1002/anie.200462960

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Designer drug: A polymer therapeutic was designed for a combination therapy of breast cancer. N-(2-Hydroxypropyl) methacrylamide was used as the model polymer platform to prepare a unimolecular polymer conjugate (see picture, radius of gyration: 12.8 nm) that combines an endocrine (the aromatase inhibitor aminoglutethimide, blue) and a chemotherapeutic agent (the anthraxcycline antibiotic doxorubidn, red). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4061 / 4066

页数：6

共 41 条

[1] Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].