Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs

被引：22

作者：

Comstock, Lindsay R. ^{[1
]}

Denu, John M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 19期

关键词：

D O I：

10.1039/b710231c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic routes for the preparation of O-acetyl-ADP-ribose and two novel non-hydrolyzable analogs containing an N-acetyl are described and shown to interact with the macro domain of histone protein H2A1.1.

引用

页码：3087 / 3091

页数：5

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