Targeted Imaging and Therapy of Brain Cancer Using Theranostic Nanoparticles

被引：94

作者：

Bhojani, Mahaveer Swaroop ^{[2
]}

Van Dort, Marcian ^{[1
]}

Rehemtulla, Alnawaz ^{[2
]}

Ross, Brian D. ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiol, Ctr Mol Imaging, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

MOLECULAR PHARMACEUTICS | 2010年 / 7卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Nanoparticle; MRI; Photodynamic therapy; F3 and RGD peptides; toxicity; cancer therapy; IRON-OXIDE NANOPARTICLES; ENDOTHELIAL-CELLS; DRUG-DELIVERY; MRI; NANOMEDICINE; TUMORS; ENHANCEMENT; PHARMACOKINETICS; CONJUGATE; DIAGNOSIS;

D O I：

10.1021/mp100298r

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The past decade has seen momentous development in brain cancer research in terms of novel imaging-assisted surgeries, molecularly targeted drug-based treatment regimens or adjuvant therapies and in our understanding of molecular footprints of initiation and progression of malignancy. However, mortality due to brain cancer has essentially remained unchanged in the last three decades. Thus, paradigm-changing diagnostic and therapeutic reagents are urgently needed. Nanotheranostic platforms are powerful tools for imaging and treatment of cancer. Multifunctionality of these nanovehicles offers a number of advantages over conventional agents. These include targeting to a diseased site thereby minimizing systemic toxicity, the ability to solubilize hydrophobic or labile drugs leading to improved pharmacokinetics and their potential to image, treat and predict therapeutic response. In this article, we will discuss the application of newer theranostic nanoparticles in targeted brain cancer imaging and treatment.

引用

页码：1921 / 1929

页数：9

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