The use of oscillatory signals in the study of genetic networks

被引：46

作者：

Lipan, O

Wong, WH

机构：

[1] Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA

[2] Stanford Univ, Dept Stat, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 20期

关键词：

systems biology; synthetic biology; stochastic processes;

D O I：

10.1073/pnas.0403790102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.

引用

收藏

页码：7063 / 7068

页数：6

相关论文

共 25 条

[1] Engineering stability in gene networks by autoregulation [J].

Becskei, A ;

Serrano, L .

NATURE, 2000, 405 (6786) :590-593

[2] ON THE RECOVERY AND RESOLUTION OF EXPONENTIAL RELAXATION RATES FROM EXPERIMENTAL-DATA .3. THE EFFECT OF SAMPLING AND TRUNCATION OF DATA ON THE LAPLACE TRANSFORM INVERSION [J].

BERTERO, M ;

BRIANZI, P ;

PIKE, ER .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1985, 398 (1814) :23-44

[3]

GADGIL C, 2005, IN PRESS B MATH BIOL

[4] Inferring genetic networks and identifying compound mode of action via expression profiling [J].

Gardner, TS ;

di Bernardo, D ;

Lorenz, D ;

Collins, JJ .

SCIENCE, 2003, 301 (5629) :102-105

[5] Synthetic gene network for entraining and amplifying cellular oscillations -: art. no. 148101 [J].

Hasty, J ;

Dolnik, M ;

Rottschäfer, V ;

Collins, JJ .

PHYSICAL REVIEW LETTERS, 2002, 88 (14) :148101/1-148101/4

[6] Prediction and measurement of an autoregulatory genetic module [J].

Isaacs, FJ ;

Hasty, J ;

Cantor, CR ;

Collins, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7714-7719

[7] REGULATED EXPRESSION OF THE NEURAL CELL-ADHESION MOLECULE L1 BY SPECIFIC PATTERNS OF NEURAL IMPULSES [J].

ITOH, K ;

STEVENS, B ;

SCHACHNER, M ;

FIELDS, RD .

SCIENCE, 1995, 270 (5240) :1369-1372

[8] Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping [J].

Izumo, M ;

Johnson, CH ;

Yamazaki, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :16089-16094

[9] TRANSCRIPTION AND TRANSLATION INITIATION FREQUENCIES OF ESCHERICHIA-COLI LAC OPERON [J].

KENNELL, D ;

RIEZMAN, H .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 114 (01) :1-21

[10] Transcriptional regulatory networks in Saccharomyces cerevisiae [J].

Lee, TI ;

Rinaldi, NJ ;

Robert, F ;

Odom, DT ;

Bar-Joseph, Z ;

Gerber, GK ;

Hannett, NM ;

Harbison, CT ;

Thompson, CM ;

Simon, I ;

Zeitlinger, J ;

Jennings, EG ;

Murray, HL ;

Gordon, DB ;

Ren, B ;

Wyrick, JJ ;

Tagne, JB ;

Volkert, TL ;

Fraenkel, E ;

Gifford, DK ;

Young, RA .

SCIENCE, 2002, 298 (5594) :799-804