The use of oscillatory signals in the study of genetic networks

被引：46

作者：

Lipan, O

Wong, WH

机构：

[1] Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA

[2] Stanford Univ, Dept Stat, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 20期

关键词：

systems biology; synthetic biology; stochastic processes;

D O I：

10.1073/pnas.0403790102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.

引用

收藏

页码：7063 / 7068

页数：6

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