Development of North American Consensus Guidelines for Medical Laboratories That Perform and Interpret Platelet Function Testing Using Light Transmission Aggregometry

被引:129
作者
Hayward, Catherine P. M. [1 ,2 ,3 ,4 ]
Moffat, Karen A. [2 ,3 ,4 ]
Raby, Anne [5 ]
Israels, Sara [3 ,6 ]
Plumhoff, Elizabeth [3 ,7 ]
Flynn, Greg [5 ]
Zehnder, James L. [3 ,8 ]
机构
[1] McMaster Univ, Michael DeGroote Sch Med, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada
[3] N Amer Specialized Coagulat Lab Assoc, Rochester, MN USA
[4] Hamilton Reg Lab, Program Med, Hamilton, ON, Canada
[5] Qual Management Program Lab Serv, Toronto, ON, Canada
[6] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada
[7] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
[8] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
关键词
Platelet function; Platelet aggregation; Light transmission aggregometry; Inherited platelet disorders; Acquired platelet disorders; Bleeding time; DIAGNOSTIC EVALUATION; REFERENCE INTERVALS; RICH PLASMA; DISORDERS; AGGREGATION; COUNT;
D O I
10.1309/AJCP9V3RRVNZMKDS
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and reduce unnecessary testing variances by developing North American guidelines on platelet function testing. Guidelines were developed by consensus for expert recommendations (minimum level for approval, 70%) that included recommendations on the evaluation and interpretation of light transmission platelet aggregometry (LTA). To assess consensus, medical opinions on recommendations were gathered from diagnostic laboratories that perform LTA, in collaboration with the Quality Management Program Laboratory Services (QMP-LS) in Ontario, Canada (10 laboratories), and the North American Specialized Coagulation Laboratory Association (NASCOLA; 47 laboratories, 5 overlapping the QMP-LS group). Adequate consensus was achieved for all and 89% of recommendations for the QMP-LS and NASCOLA groups, respectively. The recommendations adopted provide North American laboratories with additional guidance on platelet function testing, including how to interpret LTA abnormalities.
引用
收藏
页码:955 / 963
页数:9
相关论文
共 26 条
[1]  
[Anonymous], 1988, J Clin Pathol, V41, P1322
[2]  
[Anonymous], 2008, H58A CLSI
[3]   Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH [J].
Cattaneo, M. ;
Hayward, C. P. M. ;
Moffat, K. A. ;
Pugliano, M. T. ;
Liu, Y. ;
Michelson, A. D. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (06) :1029-1029
[4]   Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count [J].
Cattaneo, Marco ;
Lecchi, Anna ;
Zighetti, Maddalena Loredana ;
Lussana, Federico .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (05) :694-697
[5]   Light Transmission Aggregometry and ATP Release for the Diagnostic Assessment of Platelet Function [J].
Cattaneo, Marco .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2009, 35 (02) :158-167
[6]   Methodology and outcomes of platelet aggregation testing in Australia, New Zealand and the Asia-Pacific region: results of a survey from the Royal College of Pathologists of Australasia Haematology Quality Assurance Program [J].
Duncan, E. M. ;
Bonar, R. ;
Rodgers, S. E. ;
Favaloro, E. J. ;
Marsden, K. .
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2009, 31 (04) :398-406
[7]   Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with vonWillebrand disease type 2B: a cohort study of 67 patients [J].
Federici, Augusto B. ;
Mannucci, Pier M. ;
Castaman, Giancarlo ;
Baronciani, Luciano ;
Bucciarelli, Paolo ;
Canciani, Maria T. ;
Pecci, Alessandro ;
Lenting, Peter J. ;
De Groot, Philip G. .
BLOOD, 2009, 113 (03) :526-534
[8]   Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments [J].
Hayward, C. P. M. ;
Pai, M. ;
Liu, Y. ;
Moffat, K. A. ;
Seecharan, J. ;
Webert, K. E. ;
Cook, R. J. ;
Heddle, N. M. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (04) :676-684
[9]   An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts [J].
Hayward, Catherine P. M. ;
Moffat, Karen A. ;
Pai, Menaka ;
Liu, Yang ;
Seecharan, Jodi ;
McKay, Heather ;
Webert, Kathryn E. ;
Cook, Richard J. ;
Heddle, Nancy M. .
THROMBOSIS AND HAEMOSTASIS, 2008, 100 (01) :134-145
[10]   Diagnostic approach to platelet function disorders [J].
Hayward, Catherine P. M. .
TRANSFUSION AND APHERESIS SCIENCE, 2008, 38 (01) :65-76