Catalytic, asymmetric synthesis of cyanohydrin ethyl carbonates

被引：105

作者：

Belokon, YN

Blacker, AJ

Clutterbuck, LA

North, M ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia

[3] Avecia Ltd, Huddersfield HD2 1GA, W Yorkshire, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol035828f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bimetallic titanium complex [(salen)TiO](2), where salen is the ligand derived from (R,R)-cyclohexanediamine and 3,5-di-tert-butyl-salicylaldehyde, has been shown to catalyze the asymmetric addition of ethyl cyanoformate to aldehydes leading to cyanohydrin carbonates with high enantiomeric excesses.

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页码：4505 / 4507

页数：3

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