In vivo analysis of the molecular genetics of acute promyelocytic leukemia

被引：44

作者：

Pandolfi, PP ^{[1
]}

机构：

[1] Cornell Univ, Program Mol Biol, Dept Pathol, Sloan Kettering Div,Grad Sch Med Sci, New York, NY 10021 USA

来源：

ONCOGENE | 2001年 / 20卷 / 40期

关键词：

APL; cancer; transgenic mice; KO mice; animal models; transcription factors;

D O I：

10.1038/sj.onc.1204600

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute promyelocytic leukemia (APL) is a distinct and paradigmatic subtype of myeloid leukemia associated with reciprocal chromosomal translocations always involving the Retinoic Acid Receptor alpha (RAR alpha) gene on chromosome 17 and variable partner genes (X genes) on different chromosomes. As a consequence of these translocations X-RAR alpha and RAR alpha -X fusion genes are generated. RAR alpha fuses to the PML gene in the vast majority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes respectively. In the last few years, the functions of these aberrant fusion proteins and of the normal gene products involved in these translocations have been extensively characterized in vivo in transgenic and KO animal models. Here we will review the important conclusions, the novel questions and paradoxes that stem from this analysis.

引用

页码：5726 / 5735

页数：10

共 58 条

[11] Regulation of p53 activity in nuclear bodies by a specific PML isoform
Fogal, V
Gostissa, M
Sandy, P
Zacchi, P
Sternsdorf, T
Jensen, K
Pandolfi, PP
Will, H
Schneider, C
Del Sal, G
[J]. EMBO JOURNAL, 2000, 19 (22) : 6185 - 6195
[12] CHARACTERIZATION OF A ZINC FINGER GENE DISRUPTED BY THE T(15,17) IN ACUTE PROMYELOCYTIC LEUKEMIA
GODDARD, AD
BORROW, J
FREEMONT, PS
SOLOMON, E
[J]. SCIENCE, 1991, 254 (5036) : 1371 - 1374
[13] Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
Grignani, F
De Matteis, S
Nervi, C
Tomassoni, L
Gelmetti, V
Cioce, M
Fanelli, M
Ruthardt, M
Ferrara, FF
Zamir, I
Seiser, C
Grignani, F
Lazar, MA
Minucci, S
Pelicci, PG
[J]. NATURE, 1998, 391 (6669) : 815 - 818
[14] Grimwade D, 1997, BLOOD, V90, P4876
[15] Grimwade D, 1996, BRIT J HAEMATOL, V94, P557
[16] EARLY MYELOID CELL-SPECIFIC EXPRESSION OF THE HUMAN CATHEPSIN-G GENE IN TRANSGENIC MICE
GRISOLANO, JL
SCLAR, GM
LEY, TJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) : 8989 - 8993
[17] Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences
Grisolano, JL
Wesselschmidt, RL
Pelicci, PG
Ley, TJ
[J]. BLOOD, 1997, 89 (02) : 376 - 387
[18] Histone acetylation in chromatin structure and transcription
Grunstein, M
[J]. NATURE, 1997, 389 (6649) : 349 - 352
[19] Gudas Lorraine J., 1994, P443
[20] The function of PML in p53-dependent apoptosis
Guo, A
Salomoni, P
Luo, JY
Shih, A
Zhong, S
Gu, W
Pandolfi, PP
[J]. NATURE CELL BIOLOGY, 2000, 2 (10) : 730 - 736

← 1 2 3 4 5 6 →