Endothelial progenitor cells: a new target for the prevention of cardiovascular diseases

被引：16

作者：

Brixius, Klara

Funcke, Fabienne

Graf, Christine ^{[2
]}

Bloch, Wilhelm ^{[1
]}

机构：

[1] German Sport Univ Cologne, Inst Cardiol & Sport Med, Dept Mol & Cellular Sport Med, D-50933 Cologne, Germany

[2] German Sport Univ Cologne, Dept Cardiol & Sport Med, D-50933 Cologne, Germany

来源：

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2006年 / 13卷 / 05期

关键词：

coronary artery disease; endothelial progenitor cells; exercise; review; stem cell therapy;

D O I：

10.1097/01.hjr.0000221862.34662.31

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial progenitor cells (EPCs) are circulating precursor cells that have been implicated recently in vascular and cardiac regeneration. There is an ongoing discussion on the immunocytological definition of EPCs, based on various surface markers, and currently different cell types are included in the term 'EPC'. This review summarizes the mechanisms that influence function, survival, mobilization and differentiation of EPCs. Furthermore, there are several reports on the clinical use of EPCs for the treatment of cardiovascular diseases. We have focused specifically on the influence of physical activity on EPC function. Eur J Cardiovasc Prev Rehabil 13:705-710 (C) 2006 The European Society of Cardiology

引用

页码：705 / 710

页数：6

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