Polysaccharides as building blocks for nanotherapeutics

被引：312

作者：

Mizrahy, Shoshy ^{[1
,2
]}

Peer, Dan ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Georg S Wise Fac Life Sci, Dept Cell Res & Immunol, Lab Nanomed, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

基金：

以色列科学基金会;

关键词：

DRUG-DELIVERY SYSTEMS; POLYELECTROLYTE COMPLEXES; BIOMEDICAL APPLICATIONS; GENE DELIVERY; CHITOSAN NANOPARTICLES; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; ENDOSOMAL ESCAPE; PROTEIN-DELIVERY; CANCER-THERAPY;

D O I：

10.1039/c1cs15239d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of polysaccharides as building blocks in the development of nano-sized drug delivery systems is rapidly growing. This can be attributed to the outstanding virtues of polysaccharides such as biocompatibility, biodegradability, low toxicity and low cost. In addition, the variety of physicochemical properties and the ease of chemical modifications enable the preparation of a wide array of nanoparticles. This tutorial review describes the properties of common polysaccharides, the main mechanisms for polysaccharide based-nanoparticles preparation, and provides examples from the conceptual design towards pre-clinical and clinical applications.

引用

页码：2623 / 2640

页数：18

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