Polysaccharide-Modified Synthetic Polymeric Biomaterials

被引：227

作者：

Baldwin, Aaron D. ^{[1
,2
]}

Kiick, Kristi L. ^{[1
,2
]}

机构：

[1] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA

[2] Delaware Biotechnol Inst, Newark, DE 19711 USA

来源：

BIOPOLYMERS | 2010年 / 94卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

biomaterial; polysaccharide-modified polymer; polysaccharide conjugates; hydrogel; FIBROBLAST-GROWTH-FACTOR; HEPARIN-CARRYING POLYSTYRENE; GLYCOL) STAR COPOLYMER; LACTIC-ACID OLIGOMERS; IN-VIVO ANGIOGENESIS; PEG-GRAFTED CHITOSAN; CROSS-LINKED GEL; HYALURONIC-ACID; CHONDROITIN SULFATE; CONTROLLED-RELEASE;

D O I：

10.1002/bip.21334

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents an overview of polysaccharide-conjugated synthetic polymers and their use in tissue-engineered scaffolds and drug-delivery applications. This topic will be divided into four categories: (1) polymeric materials modified with non-mammalian polysaccharides such as alginate, chitin, and dextran; (2) polymers modified with mammalian polysaccharides such as hyaluronan, chondroitin sulfate, and heparin; (3) multi-polysaccharide-derivatized polymer conjugate systems; and (4) polymers containing polysaccharidemimetic molecules. Each section will discuss relevant conjugation techniques, analysis, and the impact of these materials as micelles, particles, or hydrogels to sed in in-vitro and in-vivo biomaterial applications. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 128-140, 2010.

引用

页码：128 / 140

页数：13

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