Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex

被引：25

作者：

Henniger, MSH ^{[1
]}

Wotjak, CT ^{[1
]}

Hölter, SM ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 470卷 / 1-2期

关键词：

alcohol; self-administration; NR2B subunit; protein; up-regulation;

D O I：

10.1016/S0014-2999(03)01787-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Forced ethanol drinking for several days and application of ethanol to cell cultures changes expression levels of various NMDA receptor subunits in rodents. We investigated the influence of long-term voluntary ethanol consumption of moderate ethanol doses on polypeptide levels of the NMDA receptor subunit 2B (NR2B) in various forebrain regions of rats and found a mild increase selectively in the frontal cortex. This result is in accordance with and extends findings from studies using high doses of ethanol for a short period and suggests that the NR2B might be a potential target for an effective treatment of alcoholic patients. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：33 / 36

页数：4

共 21 条

[11] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].