The influence of maternal immunization on infant immune responses

被引：74

作者：

Englund, J. A. ^{[1
]}

机构：

[1] Univ Washington, Childrens Hosp & Reg Med Ctr, Dept Pediat, Seattle, WA 98105 USA

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2007年 / 137卷

关键词：

maternal antibody; pregnancy; placenta; vaccination;

D O I：

10.1016/j.jcpa.2007.04.006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The vaccination of human mothers during pregnancy leads to transplacental transfer of antibody which can provide protection to the neonate during early life. This active transfer is a receptor-mediated event with preferential transport of antibody of the IgG1 and IgG3 subclasses via the FcR(n) receptor. The efficiency of trans-placental transfer is dependent on a range of factors including: placental integrity, the total IgG concentration in maternal blood, the type of vaccine, the timing of vaccine administration during gestation, the gestational age of the fetus at birth and the IgG subclass involved. The kinetics of maternal and infant serological responses has been extensively studied using Haemophilus influenzae b (Hib) vaccination as a model. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：S16 / S19

页数：4

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