A direct approach to the synthesis of famciclovir and penciclovir

被引：20

作者：

Choudary, BM

Geen, GR

Kincey, PM

Parratt, MJ

Dales, JRM

Johnson, GP

ODonnell, S

Tudor, DW

Woods, N

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,WORTHING BN14 8QH,W SUSSEX,ENGLAND

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 05期

关键词：

D O I：

10.1080/07328319608002029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral form famciclovir in three isolated steps.

引用

页码：981 / 994

页数：14

共 19 条

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