Solubility estimation of drugs in ternary systems of interest for the antisolvent precipitation processes

被引：30

作者：

Kikic, Ireneo ^{[1
]}

De Zordi, Nicola ^{[2
]}

Moneghini, Mariarosa ^{[2
]}

Solinas, Dario ^{[1
]}

机构：

[1] Univ Trieste, Dept Mat & Nat Resources, I-34127 Trieste, Italy

[2] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2010年 / 55卷 / 02期

关键词：

Drug solubility; Supercritical fluids; Thermodynamic modeling; Precipitation; SUPERCRITICAL CARBON-DIOXIDE; VAPOR-LIQUID-EQUILIBRIA; EQUATION-OF-STATE; MIXTURES; MICRONIZATION; NAPROXEN; SOLVENTS; DESIGN; FLUIDS;

D O I：

10.1016/j.supflu.2010.09.034

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Drug solubility in compressed carbon dioxide is usually low, and for this reason, CO2 is not considered a suitable solvent. However, it can be used as antisolvent to crystallize a solute from a liquid solution. The choice of optimal pressure and the CO2/drug solution ratio is a crucial point of the process, and these values must be optimized. An estimation method based on the Peng-Robinson's equation of state is presented here with which to calculate the solubility of drugs such as Acetaminophen, Acyclovir, Atenolol, Carbamazepine, Ibuprofen, Naproxen, Nimesulide, and Sotalol hydrochloride in mixtures of CO2 and common organic solvents at a constant temperature but a variable pressure. The model temperature was 298 K for Ibuprofen and Naproxen, 315 K for Acetaminophen and 313 K for any other systems. This method is a practical and rapid alternative to experimental determination. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：616 / 622

页数：7

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