Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew

被引：43

作者：

Kobayashi, J ^{[1
]}

Hosoyama, H

Wang, XX

Shigemori, H

Sudo, Y

Tsuruo, T

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Tokyo 1700012, Japan

[3] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(98)00262-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Taxuspine C (1), a new taxoid from the Japanese yew Taxus cuspidata, increasing the cellular accumulation of vincristine (VCR) in multidrug-resistant tumor cells as potent as verapamil enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice. When taxuspine C (1) was given i.p. daily at 200 mg/kg with 0.2 mg/kg VCR for 5 days, a treated/control (T/C) value of 138% was obtained. The other new taxoids, taxezopidines G (8) and H (9), from the yew also increased the VCR accumulation as potent as verapamil. These results suggest that some taxoids may be useful for overcoming multidrug resistance in tumor cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1555 / 1558

页数：4

共 11 条

[1] Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells [J].

Kobayashi, J ;

Hosoyama, H ;

Wang, XX ;

Shigemori, H ;

Koiso, Y ;

Iwasaki, S ;

Sasaki, T ;

Naito, M ;

Tsuruo, T .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) :393-398

[2] Bioactive taxoids from Japanese yew Taxus cuspidata and taxol biosynthesis [J].

Kobayashi, J ;

Shigemori, H .

HETEROCYCLES, 1998, 47 (02) :1111-1133

[3] TAXUSPINES-A-C, NEW TAXOIDS FROM JAPANESE YEW TAXUS-CUSPIDATA INHIBITING DRUG TRANSPORT ACTIVITY OF P-GLYCOPROTEIN IN MULTIDRUG-RESISTANT CELLS [J].

KOBAYASHI, J ;

OGIWARA, A ;

HOSOYAMA, H ;

SHIGEMORI, H ;

YOSHIDA, N ;

SASAKI, T ;

LI, Y ;

IWASAKI, S ;

NAITO, M ;

TSURUO, T .

TETRAHEDRON, 1994, 50 (25) :7401-7416

[4]

KOBAYASHI J, 1997, TETRAHEDRON, V38, P7587

[5]

NAITO M, 1988, J BIOL CHEM, V263, P11887

[6] New taxanes as highly efficient reversal agents for multi-drug resistance in cancer cells [J].

Ojima, I ;

Bounaud, PY ;

Takeuchi, C ;

Pera, P ;

Bernacki, RJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (02) :189-194

[7] GENETIC AND BIOCHEMICAL-CHARACTERIZATION OF MULTIDRUG RESISTANCE [J].

RIORDAN, JR ;

LING, V .

PHARMACOLOGY & THERAPEUTICS, 1985, 28 (01) :51-75

[8]

TSURUO T, 1986, JPN J CANCER RES, V77, P682

[9]

TWENTYMAN PR, 1988, ANTICANCER RES, V8, P985

[10] Taxezopidine A, a novel taxoid from seeds of Japanese yew Taxus cuspidata [J].

Wang, XX ;

Shigemori, H ;

Kobayashi, J .

TETRAHEDRON LETTERS, 1997, 38 (43) :7587-7588

← 1 2 →