New taxanes as highly efficient reversal agents for multi-drug resistance in cancer cells

被引：54

作者：

Ojima, I ^{[1
]}

Bounaud, PY

Takeuchi, C

Pera, P

Bernacki, RJ

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

[2] Roswell Pk Canc Inst, Grace Canc Drug Ctr, Dept Expt Therapeut, Buffalo, NY 14263 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10218-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (less than or equal to 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：189 / 194

页数：6

相关论文

共 14 条

[1]

CHAUFFERT B, 1986, CANCER RES, V46, P825

[2] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL [J].

DENIS, JN ;

GREENE, AE ;

GUENARD, D ;

GUERITTEVOEGELEIN, F ;

MANGATAL, L ;

POTIER, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) :5917-5919

[3]

FORD JM, 1990, PHARMACOL REV, V42, P155

[4]

FORD JM, 1989, MOL PHARMACOL, V35, P105

[5] BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER [J].

GOTTESMAN, MM ;

PASTAN, I .

ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 :385-427

[6] A CHEMOSELECTIVE APPROACH TO FUNCTIONALIZE THE C-10 POSITION OF 10-DEACETYLBACCATIN-III - SYNTHESIS AND BIOLOGICAL PROPERTIES OF NOVEL C-10 TAXOL(R) ANALOGS [J].

KANT, J ;

OKEEFFE, WS ;

CHEN, SH ;

FARINA, V ;

FAIRCHILD, C ;

JOHNSTON, K ;

KADOW, JF ;

LONG, BH ;

VYAS, D .

TETRAHEDRON LETTERS, 1994, 35 (31) :5543-5546

[7] Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells [J].

Kobayashi, J ;

Hosoyama, H ;

Wang, XX ;

Shigemori, H ;

Koiso, Y ;

Iwasaki, S ;

Sasaki, T ;

Naito, M ;

Tsuruo, T .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) :393-398

[8] TAXUSPINES-A-C, NEW TAXOIDS FROM JAPANESE YEW TAXUS-CUSPIDATA INHIBITING DRUG TRANSPORT ACTIVITY OF P-GLYCOPROTEIN IN MULTIDRUG-RESISTANT CELLS [J].

KOBAYASHI, J ;

OGIWARA, A ;

HOSOYAMA, H ;

SHIGEMORI, H ;

YOSHIDA, N ;

SASAKI, T ;

LI, Y ;

IWASAKI, S ;

NAITO, M ;

TSURUO, T .

TETRAHEDRON, 1994, 50 (25) :7401-7416

[9] REVERSAL OF MULTIDRUG RESISTANCE BY AN IMMUNOSUPPRESSIVE AGENT FK-506 [J].

NAITO, M ;

OHHARA, T ;

YAMAZAKI, A ;

DANKI, T ;

TSURUO, T .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1992, 29 (03) :195-200

[10] CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF C-2 TAXOIDS [J].

NICOLAOU, KC ;

RENAUD, J ;

NANTERMET, PG ;

COULADOUROS, EA ;

GUY, RK ;

WRASIDLO, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (09) :2409-2420