Synthesis of glycosylated β-amino hydroxamates as new class of antimalarials

被引：35

作者：

Mishra, RC

Tripathi, R ^{[1
]}

Katiyar, D

Tewari, N

Singh, D

Tripathi, RP ^{[1
]}

机构：

[1] Cent Drug Res Inst, Dept Med Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 24期

关键词：

D O I：

10.1016/j.bmc.2003.09.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylated beta-amino acids (3-18, 38, 39), obtained by hydrolysis of glycosylated beta-amino esters on reaction with hydroxylamine hydrochloride in presence of DIC/DCC afforded glycosyl beta-amino hydroxamates (19-34, 40, 41) in fair to good yields. Compounds (19-34, 40, 41) were screened against human malarial parasite Plasmodium falciparum in vitro for their schizontocidal activity. Compounds (19, 24, 26, 28, 40 and 41) exhibited good activity at 2 mug/mL concentrations. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：5363 / 5374

页数：12

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