Interrogating the T cell synapse with patterned surfaces and photactivated proteins

被引：13

作者：

DeMond, Andrew L. ^{[1
,2
]}

Groves, Jay T. ^{[1
,2
]}

机构：

[1] Biophys Grad Grp, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.coi.2007.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunological synapse is a site rich in spatially modulated signaling cascades. The importance of spatial organization in intercellular signal transduction has prompted much recent interest in techniques to control the localization of cell-surface signaling molecules to investigate synaptic signaling. Photoactivation, patterning, and mechanical constraint of surface-associated molecules are three prominent examples of such techniques. Recent results have demonstrated the effectiveness of these techniques as tools to investigate the mechanisms of immune synapse assembly and synaptic signaling.

引用

页码：722 / 727

页数：6

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