Immunologic Characteristics of Preeclampsia, a Comprehensive Review

被引：82

作者：

Ahn, Hyunkyong ^{[1
,2
,3
]}

Park, Jooncheol ^{[1
,4
]}

Gilman-Sachs, Alice ^{[5
]}

Kwak-Kim, Joanne ^{[1
,5
]}

机构：

[1] Rosalind Franklin Univ Med & Sci, Dept Obstet & Gynecol, Chicago Med Sch, N Chicago, IL 60061 USA

[2] Kwandong Univ, Dept Obstet & Gynecol, Cheil Gen Hosp, Coll Med, Seoul, South Korea

[3] Kwandong Univ, Womens Healthcare Ctr, Coll Med, Seoul, South Korea

[4] Keimyung Univ, Dept Obstet & Gynecol, Sch Med, Taegu, South Korea

[5] Rosalind Franklin Univ Med & Sci, Dept Microbiol & Immunol, Chicago Med Sch, Vernon Hills, IL 60061 USA

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2011年 / 65卷 / 04期

关键词：

Immune response; inflammation; preeclampsia; thrombophilia; NECROSIS-FACTOR-ALPHA; FACTOR-V-LEIDEN; NATURAL-KILLER-CELLS; TOLL-LIKE RECEPTOR-2; INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ALLOGENEIC FETAL REJECTION; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; ANTIPHOSPHOLIPID ANTIBODIES;

D O I：

10.1111/j.1600-0897.2010.00913.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Preeclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. Despite decades of intense research on the problem, there is no early pregnancy screening test to recognize those at risk. Recently, altered immune responses have been suspected to be involved in preeclampsia pathogenesis, which may involve the inflammatory context in which an immune response is mounted. In this review, the immunologic pathogenesis of the PE is reviewed in context of innate and adaptive immunity (both cellular, i.e., T and NK cells, and humoral immunity) in relation to thrombophilic conditions.

引用

页码：377 / 394

页数：18

共 236 条

[71] Decidual NK cells regulate key developmental processes at the human fetal-maternal interface [J].