Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

被引：74

作者：

Shenoy, Avinash R. ^{[1
]}

Kim, Bae-Hoon ^{[1
]}

Choi, Han-Pil ^{[1
]}

Matsuzawa, Takeshi ^{[1
]}

Tiwari, Sangeeta ^{[1
]}

MacMicking, John D. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06510 USA

来源：

IMMUNOBIOLOGY | 2007年 / 212卷 / 9-10期

关键词：

macrophage; IFN-gamma; p47; IRG; GBP; GTPase; phagosome; autophagy;

D O I：

10.1016/j.imbio.2007.09.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type 11 interferon (IFN-gamma) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-gamma-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases-p47 IRGs and p65 GBPs-that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice. (c) 2007 Elsevier GrnbH. All rights reserved.

引用

页码：771 / 784

页数：14

共 93 条

[1] Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus [J].

Anderson, SL ;

Carton, JM ;

Lou, J ;

Xing, L ;

Rubin, BY .

VIROLOGY, 1999, 256 (01) :8-14

[2]

[Anonymous], 2002, Immunology and evolution of infectious disease

[3] The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage [J].

Bekpen, C ;

Hunn, JP ;

Rohde, C ;

Parvanova, I ;

Guethlein, L ;

Dunn, DM ;

Glowalla, E ;

Leptin, M ;

Howard, JC .

GENOME BIOLOGY, 2005, 6 (11)

[4] The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice [J].

Bernstein-Hanley, Isaac ;

Coers, Jorn ;

Balsara, Zarine R. ;

Taylor, Gregory A. ;

Starnbach, Michael N. ;

Dietrich, William F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14092-14097

[5]

Boehm U, 1998, J IMMUNOL, V161, P6715

[6]

BRIKEN V, 1995, MOL CELL BIOL, V15, P975

[7] p47 GTPases regulate Toxoplasma gondii survival in activated macrophages [J].

Butcher, BA ;

Greene, RI ;

Henry, SC ;

Annecharico, KL ;

Weinberg, JB ;

Denkers, EY ;

Sher, A ;

Taylor, GA .

INFECTION AND IMMUNITY, 2005, 73 (06) :3278-3286

[8]

Carlow DA, 1998, J IMMUNOL, V161, P2348

[9] Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain [J].

Carter, CC ;

Gorbacheva, VY ;

Vestal, DJ .

ARCHIVES OF VIROLOGY, 2005, 150 (06) :1213-1220

[10] P-Match: transcription factor binding site search by combining patterns and weight matrices [J].

Chekmenev, DS ;

Haid, C ;

Kel, AE .

NUCLEIC ACIDS RESEARCH, 2005, 33 :W432-W437

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