Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

被引：74

作者：

Shenoy, Avinash R. ^{[1
]}

Kim, Bae-Hoon ^{[1
]}

Choi, Han-Pil ^{[1
]}

Matsuzawa, Takeshi ^{[1
]}

Tiwari, Sangeeta ^{[1
]}

MacMicking, John D. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06510 USA

来源：

IMMUNOBIOLOGY | 2007年 / 212卷 / 9-10期

关键词：

macrophage; IFN-gamma; p47; IRG; GBP; GTPase; phagosome; autophagy;

D O I：

10.1016/j.imbio.2007.09.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type 11 interferon (IFN-gamma) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-gamma-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases-p47 IRGs and p65 GBPs-that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice. (c) 2007 Elsevier GrnbH. All rights reserved.

引用

页码：771 / 784

页数：14

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