Continuous molecular enrichment in microfluidic systems

被引:13
作者
Castell, Oliver K. [1 ,2 ]
Allender, Christopher J. [1 ]
Barrow, David A. [2 ]
机构
[1] Cardiff Univ, Welsh Sch Pharm, Mol Recognit Res Unit, Cardiff, S Glam, Wales
[2] Cardiff Univ, Sch Engn, metaFAB, The Parade, Cardiff, S Glam, Wales
关键词
D O I
10.1039/b800521d
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Highly efficient molecular extractions in continuous flow microfluidic systems are demonstrated utilising the rapid mixing properties of biphasic segmented flow in conjunction with suspended micro-particulate adsorbents. A continuous flow technique providing potential for continual on-line sample enrichment, purification and clean-up in chemical synthesis, and sample preparation.
引用
收藏
页码:1031 / 1033
页数:3
相关论文
共 9 条
[1]  
BEESLEY TE, 2001, QUANTITATIVE CHROMAT, P55
[2]   The intensification of rapid reactions in multiphase systems using slug flow in capillaries [J].
Burns, JR ;
Ramshaw, C .
LAB ON A CHIP, 2001, 1 (01) :10-15
[3]   Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents [J].
Castell, Oliver K. ;
Allender, Christopher J. ;
Barrow, David A. .
BIOSENSORS & BIOELECTRONICS, 2006, 22 (04) :526-533
[4]   Diffusion coefficient measurement in a microfluidic analyzer using dual-beam microscale-refractive index gradient detection - Application to on-chip molecular size determination [J].
Costin, CD ;
Olund, RK ;
Staggemeier, BA ;
Torgerson, AK ;
Synovec, RE .
JOURNAL OF CHROMATOGRAPHY A, 2003, 1013 (1-2) :77-91
[5]   A numerical model for segmented flow in a microreactor [J].
Harries, N ;
Burns, JR ;
Barrow, DA ;
Ramshaw, C .
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 2003, 46 (17) :3313-3322
[6]   PARTITION COEFFICIENTS AND THEIR USES [J].
LEO, A ;
HANSCH, C ;
ELKINS, D .
CHEMICAL REVIEWS, 1971, 71 (06) :525-+
[7]   Molecularly imprinted polymers: A bridge to advanced drug delivery [J].
Sellergren, B ;
Allender, CJ .
ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (12) :1733-1741
[8]   A microfluidic system for controlling reaction networks in time [J].
Song, H ;
Tice, JD ;
Ismagilov, RF .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (07) :768-772
[9]   Monodisperse, molecularly imprinted polymer microspheres prepared by precipitation polymerization for affinity separation applications [J].
Wang, JF ;
Cormack, PAG ;
Sherrington, DC ;
Khoshdel, E .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (43) :5336-5338