Activation of plasmacytoid dendritic cells

被引：28

作者：

Fuchsberger, M

Hochrein, H

O'Keeffe, M

机构：

[1] Bavarian Nord GmbH, Immunol Res, D-82152 Martinsried, Germany

[2] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2005年 / 83卷 / 05期

关键词：

autoimmune disease; NF-kappa B; pattern recognition receptor (PRR); plasmacytoid dendritic cell (pDC); Toll-like receptor (TLR);

D O I：

10.1111/j.1440-1711.2005.01392.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Four years after the discovery of mouse plasmacytoid dendritic cells (pDC), pDC are still very much an 'enigmatic' cell type. It is clear that pDC are potent producers of type I IFN in response to viral, bacterial and even mammalian nucleotides. The role that they play in vivo before and after activation is still under scrutiny. This review concentrates on the pathways to activation of pDC, examining the activating ligands, receptors and signalling molecules that are known to be involved, and the relevance of these activation pathways to human disease.

引用

收藏

页码：571 / 577

页数：7

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