Quantitative genetic analysis of blood pressure response during the cold pressor test

被引:24
作者
Choh, AC
Czerwinski, SA
Lee, M
Demerath, EW
Wilson, AF
Towne, B
Siervogel, RM
机构
[1] Wright State Univ, Sch Med, Lifespan Hlth Res Ctr, Kettering, OH 45420 USA
[2] NHGRI, Natl Inst Hlth, Baltimore, MD USA
关键词
genetic epidemiology; cardiovascular disease reactivity; cold pressor test; blood pressure; pleiotropy;
D O I
10.1016/j.amjhyper.2004.11.041
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: The genetic association between blood pressure (BP) at rest and during the cold pressor test (CPT) is not well characterized. The purpose of this study was to examine the genetic architecture of BP during the CPT, and to determine whether BP at rest and during the CPT share common genetic influences. Methods: In 419 individuals distributed across four large families, variance components methods were used to estimate heritabilities of resting BP and CPT BP, along with genetic correlations among BP traits. The CPT consisted of immersion of the left foot in 4 C water while the participant was supine. Blood pressure reactivity (Delta BP) was defined as BP at 15 to 30 sec and 45 to 60 sec of foot immersion minus resting BP. Results: Significant (P < .05) heritabilities were found for supine BP (h(SBP)(2) = 0.35), CPT BP (h(SBP)(2) = 0.27 and 0.33, h(DBP)(2) = 0.18 and 0.30), and Delta SBP (h(SBP)(2) = 0.12 and 0.37) but not for Delta DBP. Bivariate analyses detected significant (P < .05) genetic correlations between resting SBP and CPT SBP that were different from 0 and 1. Genetic correlations between resting DBP and CPT DBP were not significantly different from 1. Genetic correlations between resting SBP and Delta SBP were not significant. Conclusions: Measures of BP at rest and during cold immersion are significantly influenced by additive genetic effects. These genetic influences are only partially shared between SBP at rest and SBP during cold immersion, suggesting that a somewhat different set of genes may influence SBP during cold immersion. Unique sets of genes also appear to influence Delta SBP independent of those influencing resting SBP.
引用
收藏
页码:1211 / 1217
页数:7
相关论文
共 30 条
[1]   Multipoint quantitative-trait linkage analysis in general pedigrees [J].
Almasy, L ;
Blangero, J .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1198-1211
[2]  
[Anonymous], 1992, LIKELIHOOD, DOI DOI 10.56021/9780801844454
[3]   MULTIVARIATE SEGREGATION ANALYSIS USING THE MIXED MODEL [J].
BLANGERO, J ;
KONIGSBERG, LW .
GENETIC EPIDEMIOLOGY, 1991, 8 (05) :299-316
[4]   Genetic influences on blood pressure with the cold-pressor test: A twin study [J].
Busjahn, A ;
Faulhaber, HD ;
Viken, RJ ;
Rose, RJ ;
Luft, FC .
JOURNAL OF HYPERTENSION, 1996, 14 (10) :1195-1199
[5]   INFERENCE ABOUT GENETIC CORRELATIONS [J].
CAREY, G .
BEHAVIOR GENETICS, 1988, 18 (03) :329-338
[6]   GENETIC-EFFECTS ON CARDIOVASCULAR-RESPONSES TO COLD AND MENTAL ACTIVITY IN LATE ADULTHOOD [J].
CARMELLI, D ;
WARD, MM ;
REED, T ;
GRIM, CE ;
HARSHFIELD, GA ;
FABSITZ, RR .
AMERICAN JOURNAL OF HYPERTENSION, 1991, 4 (03) :239-244
[7]  
Carroll D, 1996, J HUM HYPERTENS, V10, P777
[8]   Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans [J].
Choh, AC ;
Gage, TB ;
McGarvey, ST ;
Comuzzie, AG .
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2001, 115 (04) :304-311
[9]   African American women and men at high and low risk for hypertension: A signal detection analysis of NHANES III, 1988-19941 [J].
Collins, R ;
Winkleby, MA .
PREVENTIVE MEDICINE, 2002, 35 (04) :303-312
[10]  
Czerwinski SA, 1999, GENET EPIDEMIOL, V17, pS121