The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide

被引：76

作者：

Storer, R ^{[1
]}

Ashton, CJ ^{[1
]}

Baxter, AD ^{[1
]}

Hann, MM ^{[1
]}

Marr, CLP ^{[1
]}

Mason, AM ^{[1
]}

Mo, CL ^{[1
]}

Myers, PL ^{[1
]}

Noble, SA ^{[1
]}

Penn, CR ^{[1
]}

Weir, NG ^{[1
]}

Woods, JM ^{[1
]}

Coe, PL ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 02期

关键词：

D O I：

10.1080/15257779908043068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel fluoropyrazole ribonucleoside has been shown to have significant antiinfluenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.

引用

页码：203 / 216

页数：14

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