A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes

被引：35

作者：

Gimeno, P ^{[1
]}

Besacier, F ^{[1
]}

Bottex, A ^{[1
]}

Dujourdy, L ^{[1
]}

Chaudron-Thozet, H ^{[1
]}

机构：

[1] Lab Police Sci Lyon, F-69134 Ecully, France

来源：

FORENSIC SCIENCE INTERNATIONAL | 2005年 / 155卷 / 2-3期

关键词：

3,4-methylenedioxymethamphetamine (MDMA); impurities; gas chromatography; mass spectrometry; reductive amination;

D O I：

10.1016/j.forsciint.2004.11.013

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Impurities found in various sources of precursors (sassafras oil, safrol, isosafrol, piperonal), intermediates (beta-nitroisosafrol, piperonylmethylketone (PMK)) and final product (3,4-methylenedioxymethamphetamine (MDMA)) are presented and discussed. Particular attention is paid to the chemical origin of each impurity found in the prepared samples. Impurity profiles of isosafrol, piperonal, and PMK samples obtained from industrial sources or from sassafras oil were first compared. Then PMK samples produced from isosafrol through isosafrol glycol or through beta-nitroisosafrol were compared. At last, attention was paid to the reductive amination of PMK to MDMA using different reductive agents. Possible use of this profiling method to determine the synthesis route is discussed for all products. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 157

页数：17

共 15 条

[1] SYNTHESIS MARKERS IN ILLEGALLY MANUFACTURED 3,4-METHYLENEDIOXYAMPHETAMINE AND 3,4-METHYLENEDIOXYMETHAMPHETAMINE [J].