CKD-602. Oncolytic, DNA topoisomerase I inhibitor

被引：4

作者：

Ahn, SK ^{[1
]}

Kim, JK ^{[1
]}

Hong, CI ^{[1
]}

机构：

[1] Chong Kun Dang Pharm Corp, Chong Kun Dang Res Inst, Cheonan 330830, Chungcheongnamd, South Korea

来源：

DRUGS OF THE FUTURE | 2000年 / 25卷 / 12期

关键词：

D O I：

10.1358/dof.2000.025.12.603114

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：1243 / 1246

页数：4

共 19 条

[1] Practical synthesis of (S)-7-(2-isopropylamino)ethylcamptothecin hydrochloride, potent topoisomerase I inhibitor [J].

Ahn, SK ;

Choi, NS ;

Jeong, BS ;

Kim, KK ;

Journ, DJ ;

Kim, JK ;

Lee, SJ ;

Kim, JW ;

Hong, CI ;

Jew, SS .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (05) :1141-1144

[2]

IKEDA K, 1995, P AM ASS CANC RES, V36

[3] Synthesis and antitumor activity of 7-substituted 20(RS)-campothecin analogues [J].

Jew, SP ;

Kim, HJ ;

Kim, MG ;

Roh, EY ;

Cho, YS ;

Kim, JK ;

Cha, KH ;

Lee, KK ;

Han, HJ ;

Choi, JY ;

Lee, H .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :845-848

[4] Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues [J].

Jew, SS ;

Kim, MG ;

Kim, HJ ;

Roh, EY ;

Cho, YS ;

Kim, JK ;

Cha, KH ;

Lee, KK ;

Han, HJ ;

Lee, H .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :849-852

[5] ENANTIOSELECTIVE SYNTHESIS OF 20(S)-CAMPTOTHECIN USING SHARPLESS CATALYTIC ASYMMETRIC DIHYDROXYLATION [J].

JEW, SS ;

OK, KD ;

KIM, HJ ;

KIM, MG ;

KIM, JM ;

HAH, JM ;

CHO, YS .

TETRAHEDRON-ASYMMETRY, 1995, 6 (06) :1245-1248

[6] SYNTHESIS OF WATER-SOLUBLE (AMINOALKYL)CAMPTOTHECIN ANALOGS - INHIBITION OF TOPOISOMERASE-I AND ANTITUMOR-ACTIVITY [J].

KINGSBURY, WD ;

BOEHM, JC ;

JAKAS, DR ;

HOLDEN, KG ;

HECHT, SM ;

GALLAGHER, G ;

CARANFA, MJ ;

MCCABE, FL ;

FAUCETTE, LF ;

JOHNSON, RK ;

HERTZBERG, RP .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :98-107

[7] Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor [J].

Lee, JH ;

Lee, JM ;

Kim, JK ;

Ahn, SK ;

Lee, SJ ;

Kim, MY ;

Jew, SS ;

Park, JG ;

Hong, CI .

ARCHIVES OF PHARMACAL RESEARCH, 1998, 21 (05) :581-590

[8]

LEE JH, 1998, P AM ASS CANC RES, V39

[9]

LEE JH, 2000, NEW YORK AC SCI C CA

[10]

Lee Ju-Mong, 1998, Yakhak Hoeji, V42, P431

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