Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold nanoparticles

被引：226

作者：

Kneipp, J ^{[1
]}

Kneipp, H

Rice, WL

Kneipp, K

机构：

[1] Harvard Univ, Sch Med, Wellman Ctr Photomed, Boston, MA 02139 USA

[2] Tech Univ Berlin, Dept Phys, Berlin, Germany

来源：

ANALYTICAL CHEMISTRY | 2005年 / 77卷 / 08期

关键词：

D O I：

10.1021/ac050109v

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical information from its biological environment by employing SERS in the local optical fields of the gold nanoparticles. The probe offers the potential to increase the spectral specificity and selectivity of current chemical characterization approaches of living cells and biomaterials based on vibrational information.

引用

页码：2381 / 2385

页数：5

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