Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment

被引：94

作者：

Allen, Matthew R.

Burr, David B.

机构：

[1] Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Orthopaed Surg, Indianapolis, IN 46202 USA

[3] Indiana Univ Purdue Univ, Dept Biomed Engn, Indianapolis, IN 46202 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 11期

关键词：

bisphosphonates; remodeling; toughness; biomechanics; osteoporosis;

D O I：

10.1359/JBMR.070720

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three years of daily alendronate treatment increases microdamage in vertebral bone but does not significantly increase it beyond levels of microdamage found after 1 yr of treatment. This suggests microdamage accumulation peaks during the early period of bisphosphonate treatment and does not continue to accumulate with longer periods of treatment.

引用

页码：1759 / 1765

页数：7

共 26 条

[21] Microdamage of human cortical bone: Incidence and morphology in long bones [J].