Intraadrenal mechanisms of DHEA regulation: A hypothesis for adrenopause

被引:15
作者
Alesci, S [1 ]
Bornstein, SR [1 ]
机构
[1] NICHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA
关键词
DHEA; adrenal androgens; adrenopause; aging; cellular cross-talk;
D O I
10.1055/s-2001-14826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the major androgens secreted by the human adrenal gland. The specific control of these hormones remains unclear. While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intra-adrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.
引用
收藏
页码:75 / 82
页数:8
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